Angiotensin ii
Giapreza (angiotensin ii) is a protein pharmaceutical. Angiotensin ii was first approved as Giapreza on 2017-12-21. It is used to treat hypotension in the USA. It has been approved in Europe to treat hypotension and shock. It is known to target type-2 angiotensin II receptor, proto-oncogene Mas, potassium channel subfamily K member 3, and type-1 angiotensin II receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| angiotensin ii | ANDA | 2025-06-04 |
| giapreza | New Drug Application | 2024-11-26 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Angiotensin Ii Acetate, Giapreza, La Jolla Pharma | |||
| 11219662 | 2037-01-06 | U-3262 | |
| 9220745 | 2034-12-18 | U-2217, U-2218 | |
| 10028995 | 2034-12-18 | U-2338 | |
| 10493124 | 2034-12-18 | U-2679 | |
| 11096983 | 2034-12-18 | U-3211, U-3212 | |
| 11559559 | 2034-12-18 | U-3514 | |
| 9572856 | 2031-07-18 | U-2221 | |
| 9867863 | 2029-12-16 | U-2231 | |
| 10335451 | 2029-12-16 | U-2581 | |
| 10500247 | 2029-12-16 | U-2680, U-2681 | |
| 10548943 | 2029-12-16 | U-2739, U-2740 | |
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CX: Other cardiac stimulants in atc
— C01CX09: Angiotensin ii
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DX: Angiotensin ii receptor blockers (arbs), other combinations
HCPCS
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Clinical
Clinical Trials
1663 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 4 | 40 | 24 | 32 | 101 |
| Healthy volunteers/patients | — | — | — | 35 | — | — | 1 | — | 36 |
| Essential hypertension | D000075222 | — | I10 | — | 1 | 5 | 1 | 3 | 10 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 3 | 3 | — | 6 |
| Isolated systolic hypertension | D000092244 | — | — | — | — | 1 | 1 | 1 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | 2 | — | 3 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | 2 | — | 3 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | 3 | — | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | 1 | 2 |
| Renal insufficiency | D051437 | — | N19 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systolic murmurs | D054160 | — | R01.1 | — | — | 1 | — | 1 | 2 |
| Polycystic kidney diseases | D007690 | — | Q61.3 | — | — | 2 | — | — | 2 |
| Dyslipidemias | D050171 | — | — | — | — | 1 | — | — | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | 1 | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 1 | — | — | 1 |
| Disease progression | D018450 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | — | — | 1 |
| Overweight | D050177 | — | E66.3 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Angiotensin ii |
| INN | angiotensin ii |
| Description | Ile(5)-angiotensin II is an angiotensin II that acts on the central nervous system (PDB entry: 1N9V). It has a role as a human metabolite. It is a tautomer of an Ile(5)-angiotensin II dizwitterion. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 11128-99-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL408403 |
| ChEBI ID | 2719 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | M089EFU921 (ChemIDplus, GSRS) |
Target
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Variants
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Giapreza – Innoviva
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Safety
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234 adverse events reported
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